The Historic Columbia River Highway is closed in both directions one mile west of Multnomah Falls at Mosquito Springs Creek, due to a debris slide.
Crews with the Oregon Department of Transportation are on site monitoring the landslide.
“This is a typical trouble spot in really heavy downpours,” said David House, a spokesman for ODOT.
70 cubic yards slid onto the highway and more debris may fall as the rains continue.
The highway will remain closed likely until sometime Monday, when the clean-up is complete, according to House.
A second landslide at Eagle Creek prompted ODOT to close the Interstate-84 eastbound off-ramp at milepost 41.
Landslides also closed Clackamas River Drive between OR 213 and Springwater Road and Southeast Gilbertson Road in Sandy, according to Clackamas County.
Any updates or new state road closures will be posted to TripCheck.
The National Weather Service is now predicting more moderate rainfall across western Oregon Sunday, with a reduced risk of flooding. The Wilson and Trask Rivers at Tillamook, and the Siletz River at Siletz are the most likely places to see minor flooding.
A cold front is expected Monday, which could produce gusty winds of 40-45 mph later in the day and into the evening.